Featured publications
Gut Microbes
Nuanced contribution of gut microbiome in the early brain development of mice
Yeo, Xin Yi, Woo Ri Chae, Hae Ung Lee, Han-Gyu Bae, Sven Pettersson, Joanes Grandjean, Weiping Han, and Sangyong Jung. “Nuanced Contribution of Gut Microbiome in the Early Brain Development of Mice.” Gut Microbes 15, no. 2 (December 2023): 2283911. https://doi.org/10.1080/19490976.2023.2283911.
Trends in Food Science & Technology
Strategies for Lactase Immobilization and Delivery to Relieve Lactose Intolerance
Deng, Ziyu, Qianchun Deng, Bin Li, Jing Li, Sangyong Jung*, Nam-Joon Cho*, and Hongshan Liang*. “Strategies for Lactase Immobilization and Delivery to Relieve Lactose Intolerance.” Trends in Food Science & Technology, November 2023, 104244. https://doi.org/10.1016/j.tifs.2023.104244.
*Corresponding authors
Nature
IPS-Cell-Derived Microglia Promote Brain Organoid Maturation via Cholesterol Transfer
Park, Dong Shin, Tatsuya Kozaki, Satish Kumar Tiwari, Marco Moreira, Ahad Khalilnezhad, Federico Torta, Nicolas Olivié, et al. “IPS-Cell-Derived Microglia Promote Brain Organoid Maturation via Cholesterol Transfer.” Nature 623, no. 7986 (November 9, 2023): 397–405. https://doi.org/10.1038/s41586-023-06713-1.
Journal of Cerebral Blood Flow and Metabolism
The Lateral Entorhinal Cortex Is a Hub for Local and Global Dysfunction in Early Alzheimer’s Disease States
Mandino, Francesca, Ling Yun Yeow, Renzhe Bi, Lee Sejin, Han Gyu Bae, Seung Hyun Baek, Chun-Yao Lee, et al. “The Lateral Entorhinal Cortex Is a Hub for Local and Global Dysfunction in Early Alzheimer’s Disease States.” Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism, April 25, 2022, 271678X221082016. https://doi.org/10.1177/0271678X221082016.
Journal of Hazardous Materials
Microplastics Released from Food Containers Can Suppress Lysosomal Activity in Mouse Macrophages
Deng, Jingyu, Mohammed Shahrudin Bin Ibrahim, Li Yang Tan, Xin Yi Yeo, Yong An Lee, Sung Jin Park, Torsten Wüstefeld, June-Woo Park, Sangyong Jung*, and Nam-Joon Cho*. “Microplastics Released from Food Containers Can Suppress Lysosomal Activity in Mouse Macrophages.” Journal of Hazardous Materials, April 2022, 128980. https://doi.org/10.1016/j.jhazmat.2022.128980.
Proceedings of the National Academy of Sciences (PNAS)
Destabilization of β Cell FIT2 by Saturated Fatty Acids Alter Lipid Droplet Numbers and Contribute to ER Stress and Diabetes
Zheng, Xiaofeng, Qing Wei Calvin Ho, Minni Chua, Olga Stelmashenko, Xin Yi Yeo, Sneha Muralidharan, Federico Torta, et al. “Destabilization of β Cell FIT2 by Saturated Fatty Acids Alter Lipid Droplet Numbers and Contribute to ER Stress and Diabetes.” Proceedings of the National Academy of Sciences 119, no. 11 (March 15, 2022): e2113074119. https://doi.org/10.1073/pnas.2113074119.
Brain Pathology
Ermin Deficiency Leads to Compromised Myelin, Inflammatory Milieu, and Susceptibility to Demyelinating Insult
Ziaei, Amin, Marta Garcia-Miralles, Carola I. Radulescu, Harwin Sidik, Aymeric Silvin, Han-Gyu Bae, Carine Bonnard, et al. “Ermin Deficiency Leads to Compromised Myelin, Inflammatory Milieu, and Susceptibility to Demyelinating Insult.” Brain Pathology (Zurich, Switzerland), March 13, 2022, e13064. https://doi.org/10.1111/bpa.13064.
Cancers
Imaging Kv1.3 Expressing Memory T Cells as a Marker of Immunotherapy Response
Goggi, Julian L., Shivashankar Khanapur, Boominathan Ramasamy, Siddesh V. Hartimath, Tang Jun Rong, Peter Cheng, Yun Xuan Tan, et al. “Imaging Kv1.3 Expressing Memory T Cells as a Marker of Immunotherapy Response.” Cancers 14, no. 5 (February 26, 2022): 1217. https://doi.org/10.3390/cancers14051217.
Biomedicines
Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases
Yeo, Xin Yi, Grace Cunliffe, Roger C. Ho, Su Seong Lee, and Sangyong Jung. “Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases.” Biomedicines 10, no. 2 (February 1, 2022): 343. https://doi.org/10.3390/biomedicines10020343.
Journal of Lipid Research
Abca8b promotes myelination via regulation of chondroitin sulfate proteoglycan 4 localization in oligodendrocyte precursor cells in mice
Liu Y, Castano D, Girolamo F, Trigueros-Motos L, Bae HG, Neo SP, Oh J, Narayanaswamy P, Torta F, Rye KA, Jo DG, Gunaratne J, Jung S, Virgintino D, Singaraja RR., (2021), Abca8b promotes myelination via regulation of chondroitin sulfate proteoglycan 4 localization in oligodendrocyte precursor cells in mice, Journal of Lipid Research.
Alzheimer’s Disease & Treatment
Preclinical Modeling of Alzheimer’s disease-Success and Limitations
Xin Yi Yeo, Grace Cunliffe, Tang Jiong, Jong Gigg, Zeng Li, Sangyong Jung, (2021), Preclinical Modeling of Alzheimer’s disease-Success and Limitations, In book: Alzheimer’s Disease & Treatment, Vol. 3, Chapter II.
iScience
Real-Time Three-Dimensional Tracking of Single Vesicles Reveals Abnormal Motion and Pools of Synaptic Vesicles in Neurons of Huntington’s Disease Mice
Chen, Sidong, Hanna Yoo, Chun Hei Li, Chungwon Park, Gyunam Park, Li Yang Tan, Sangyong Jung, and Hyokeun Park. “Real-Time Three-Dimensional Tracking of Single Vesicles Reveals Abnormal Motion and Pools of Synaptic Vesicles in Neurons of Huntington’s Disease Mice.” IScience 24, no. 10 (October 2021): 103181. https://doi.org/10.1016/j.isci.2021.103181.
Life
Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases?
Tan, Li Yang, Xin Yi Yeo, Han-Gyu Bae, Delia Pei Shan Lee, Roger C. Ho, Jung Eun Kim, Dong-Gyu Jo, and Sangyong Jung. “Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases?” Life 11, no. 7 (July 15, 2021): 698. https://doi.org/10.3390/life11070698.
Nature Neuroscience
A Neural Circuit for Excessive Feeding Driven by Environmental Context in Mice
Mohammad, Hasan, Esra Senol, Martin Graf, Chun-Yao Lee, Qin Li, Qing Liu, Xin Yi Yeo, et al. “A Neural Circuit for Excessive Feeding Driven by Environmental Context in Mice.” Nature Neuroscience, June 24, 2021. https://doi.org/10.1038/s41593-021-00875-9.
Proceedings of the National Academy of Sciences
Unique Dynamics and Exocytosis Properties of GABAergic Synaptic Vesicles Revealed by Three-Dimensional Single Vesicle Tracking
Park, Chungwon, Xingxiang Chen, Chong-Li Tian, Gyu Nam Park, Nicolas Chenouard, Hunki Lee, Xin Yi Yeo, et al. “Unique Dynamics and Exocytosis Properties of GABAergic Synaptic Vesicles Revealed by Three-Dimensional Single Vesicle Tracking.” Proceedings of the National Academy of Sciences 118, no. 9 (March 2, 2021): e2022133118. https://doi.org/10.1073/pnas.2022133118.
Archives of Pharmacal Research
White Matter and Neurological Disorders
Bae, Han-Gyu, Tai Kyoung Kim, Ho Young Suk, Sangyoung Jung, and Dong-Gyu Jo. “White Matter and Neurological Disorders.” Archives of Pharmacal Research 43, no. 9 (September 2020): 920–31. https://doi.org/10.1007/s12272-020-01270-x.
Science Advances
ELKS1 Controls Mast Cell Degranulation by Regulating the Transcription of Stxbp2 and Syntaxin 4 via Kdm2b Stabilization
Lam, Hiu Yan, Surendar Arumugam, Han Gyu Bae, Cheng Chun Wang, Sangyong Jung, Ashley Lauren St. John, Wanjin Hong, Weiping Han, and Vinay Tergaonkar. “ELKS1 Controls Mast Cell Degranulation by Regulating the Transcription of Stxbp2 and Syntaxin 4 via Kdm2b Stabilization.” Science Advances 6, no. 31 (July 2020): eabb2497. https://doi.org/10.1126/sciadv.abb2497.
Biological Psychiatry
Integrative Analysis Identifies Key Molecular Signatures Underlying Neurodevelopmental Deficits in Fragile X Syndrome
Utami, Kagistia Hana, Niels H. Skotte, Ana R. Colaço, Nur Amirah Binte Mohammad Yusof, Bernice Sim, Xin Yi Yeo, Han-Gyu Bae, et al. “Integrative Analysis Identifies Key Molecular Signatures Underlying Neurodevelopmental Deficits in Fragile X Syndrome.” Biological Psychiatry 88, no. 6 (September 2020): 500–511. https://doi.org/10.1016/j.biopsych.2020.05.005.
Journal of Cell Science
AP180 Promotes Release Site Clearance and Clathrin-Dependent Vesicle Reformation in Mouse Cochlear Inner Hair Cells
Kroll, Jana, Özge Demet Özçete, Sangyong Jung, Tanja Maritzen, Ira Milosevic, Carolin Wichmann, and Tobias Moser. “AP180 Promotes Release Site Clearance and Clathrin-Dependent Vesicle Reformation in Mouse Cochlear Inner Hair Cells.” Journal of Cell Science, January 1, 2019, jcs.236737. https://doi.org/10.1242/jcs.236737.
IBRO Reports
Structural and Functional Study of Orphan Nuclear Receptor Nor1 in Control of Food Intake and Energy Homeostasis
Yoo, Jun Yeob, Cong Bao Kang, Rishikesan Sankaranarayanan, Sangyong Jung, and Ho Sup Yoon. “Structural and Functional Study of Orphan Nuclear Receptor Nor1 in Control of Food Intake and Energy Homeostasis.” IBRO Reports 6 (September 2019): S306. https://doi.org/10.1016/j.ibror.2019.07.949.
Proceedings of the National Academy of Science
Intrinsic Mutant HTT-Mediated Defects in Oligodendroglia Cause Myelination Deficits and Behavioral Abnormalities in Huntington Disease
Ferrari Bardile, Costanza, Marta Garcia-Miralles, Nicholas S. Caron, Nirmala Arul Rayan, Sarah R. Langley, Nathan Harmston, Ana Maria Rondelli, et al. “Intrinsic Mutant HTT-Mediated Defects in Oligodendroglia Cause Myelination Deficits and Behavioral Abnormalities in Huntington Disease.” Proceedings of the National Academy of Sciences 116, no. 19 (May 7, 2019): 9622–27. https://doi.org/10.1073/pnas.1818042116.
Nature Communications
High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics
Mager T, Lopez de la Morena D, Senn V, Schlotte J, D Errico A, Feldbauer K, Wrobel C, Jung S, Bodensiek K, Rankovic V, Browne L, Huet A, Jüttner J, Wood PG, Letzkus JJ, Moser T, Bamberg E. (2018), High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics., Nat. Commun.
eLife
The synaptic ribbon is critical for sound encoding at high rates and with temporal precision
P. Jean, D. Lopez de la Morena, S. Michanski, L.M. Jaime Tobón, R. Chakrabarti, M.M. Picher, J. Neef, S.Y. Jung, M. Gültas, S. Maxeiner, A. Neef, C. Wichmann, N. Strenzke, C. Grabner and T. Moser. (2018), The synaptic ribbon is critical for sound encoding at high rates and with temporal precision., eLife.
Front. Cell. Neurosci
RIM-Binding Protein 2 Promotes a Large Number of CaV1.3 Ca2+-Channels and Contributes to Fast Synaptic Vesicle Replenishment at Hair Cell Active Zones
Krinner S, Butola T, Jung S, Wichmann C, Moser T. (2017), RIM-Binding Protein 2 Promotes a Large Number of CaV1.3 Ca2+-Channels and Contributes to Fast Synaptic Vesicle Replenishment at Hair Cell Active Zones., Front. Cell. Neurosci.
Front. Cell. Neurosci
Rab Interacting Molecules 2 and 3 Directly Interact with the Pore-Forming CaV1.3 Ca2+ Channel Subunit and Promote Its Membrane Expression
Maria M. Picher, Ana-Maria Opris oreanu, Sangyong Jung, Katrin Michel, Susanne Schoch and Tobias Moser. (2017), Rab Interacting Molecules 2 and 3 Directly Interact with the Pore-Forming CaV1.3 Ca2+ Channel Subunit and Promote Its Membrane Expression., Front. Cell. Neurosci.
Proc Natl Acad Sci
Ca2+-binding protein 2 inhibits Ca2+ channel inactivation in mouse inner hair cells
Maria M. Picher, Anna Gehrt, Sandra Meese, Aleksandra Ivanovic, Friederike Predoehl, Sangyong Jung, Isabelle Schrauwen, Alberto Giulio Dragonetti, Roberto Colombo, Guy van Camp, Nicola Strenzke and Tobias Moser. (2017), Ca2+-binding protein 2 inhibits Ca2+ channel inactivation in mouse inner hair cells., Proc Natl Acad Sci U S A.
Proc Natl Acad Sci
Hair cells use active zones with different voltage dependence of Ca2+ influx to decompose sounds into complementary neural codes
Ohn TL, Rutherford MA#, Jing Z#, Jung S#, Duque-Afonso CJ, Hoch G, Picher MM, Scharinger A, Strenzke N, Moser T. (2016), Hair cells use active zones with different voltage dependence of Ca2+ influx to decompose sounds into complementary neural codes. Proc Natl Acad Sci U S A., (#Equal contribution)
EMBO J
Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and heaing
Vogl C, Panou I, Yamanbaeva G, Wichmann C, Mangosing SJ, Vilardi F, Indzhykulian AA, Pangršič T, Santarelli R, Rodriguez-Ballesteros M, Weber T, Jung S, Cardenas E, Wu X, Wojcik SM, Kwan KY, Del Castillo I, Schwappach B, Strenzke N, Corey DP, Lin SY, Moser T. (2016), Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and heaing. EMBO J.
Developmental Cell
Actin Filament Turnover Drives Leading Edge Growth during Myelin Sheath Formation in the Central Nervous System
S. Nawaz, P. Sánchez, S. Schmitt, N. Snaidero, M. Mitkovski, C. Velte, B. R. Brückner, I. Alexopoulos, T. Czopka, S. Y. Jung, J. S. Rhee, A. Janshoff, W. Witke, I. A. T. Schaap, D. A. Lyons, M. Simons, Actin Filament Turnover Drives Leading Edge Growth during Myelin Sheath Formation in the Central Nervous System. Developmental Cell 34, 139–151 (2015).
EMBO J
Disruption of adaptor protein 2μ ( AP ‐2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing
S. Jung, T. Maritzen, C. Wichmann, Z. Jing, A. Neef, N. H. Revelo, H. Al‐Moyed, S. Meese, S. M. Wojcik, I. Panou, H. Bulut, P. Schu, R. Ficner, E. Reisinger, S. O. Rizzoli, J. Neef, N. Strenzke, V. Haucke, T. Moser, Disruption of adaptor protein 2μ ( AP ‐2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing. The EMBO Journal 34, 2686–2702 (2015).
PNAS
Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated Ca V 1.3 Ca 2+ channels at hair cell active zones
S. Jung, T. Oshima-Takago, R. Chakrabarti, A. B. Wong, Z. Jing, G. Yamanbaeva, M. M. Picher, S. M. Wojcik, F. Göttfert, F. Predoehl, K. Michel, S. W. Hell, S. Schoch, N. Strenzke, C. Wichmann, T. Moser, Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated Ca V 1.3 Ca 2+ channels at hair cell active zones. Proc. Natl. Acad. Sci. U.S.A. 112 (2015).
Journal of Neuroscience
Modes and Regulation of Endocytic Membrane Retrieval in Mouse Auditory Hair Cells
J. Neef, S. Jung, A. B. Wong, K. Reuter, T. Pangršič, R. Chakrabarti, S. Kügler, C. Lenz, R. Nouvian, R. M. Boumil, W. N. Frankel, C. Wichmann, T. Moser, Modes and Regulation of Endocytic Membrane Retrieval in Mouse Auditory Hair Cells. J. Neurosci. 34, 705–716 (2014).
Journal of Cell Biology 200
Neurobeachin regulates neurotransmitter receptor trafficking to synapses
R. Nair, J. Lauks, S. Jung, N. E. Cooke, H. De Wit, N. Brose, M. W. Kilimann, M. Verhage, J. Rhee, Neurobeachin regulates neurotransmitter receptor trafficking to synapses. Journal of Cell Biology 200, 61–80 (2013).
Nature Protocol
Analysis of neurotransmitter release mechanisms by photolysis of caged Ca2+ in an autaptic neuron culture system
A. Burgalossi, S. Jung, K. M. Man, R. Nair, W. J. Jockusch, S. M. Wojcik, N. Brose, J.-S. Rhee, Analysis of neurotransmitter release mechanisms by photolysis of caged Ca2+ in an autaptic neuron culture system. Nat Protoc 7, 1351–1365 (2012).
Molecular Brain
Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway
K.-J. Yoon, H.-R. Lee, Y. S. Jo, K. An, S.-Y. Jung, M.-W. Jeong, S.-K. Kwon, N.-S. Kim, H.-W. Jeong, S.-H. Ahn, K.-T. Kim, K. Lee, E. Kim, J.-H. Kim, J.-S. Choi, B.-K. Kaang, Y.-Y. Kong, Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway. Mol Brain 5, 40 (2012).
PNAS
Input-specific synaptic plasticity in the amygdala is regulated by neuroligin-1 via postsynaptic NMDA receptors
S.-Y. Jung, J. Kim, O. B. Kwon, J. H. Jung, K. An, A. Y. Jeong, C. J. Lee, Y.-B. Choi, C. H. Bailey, E. R. Kandel, J.-H. Kim, Input-specific synaptic plasticity in the amygdala is regulated by neuroligin-1 via postsynaptic NMDA receptors. Proc. Natl. Acad. Sci. U.S.A. 107, 4710–4715 (2010).
Journal of Cell Biology
Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C
C. Hsu, Y. Morohashi, S. Yoshimura, N. Manrique-Hoyos, S. Jung, M. A. Lauterbach, M. Bakhti, M. Grønborg, W. Möbius, J. Rhee, F. A. Barr, M. Simons, Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C. Journal of Cell Biology 189, 223–232 (2010).
Neuron
SNARE Protein Recycling by αSNAP and βSNAP Supports Synaptic Vesicle Priming
A. Burgalossi, S. Jung, G. Meyer, W. J. Jockusch, O. Jahn, H. Taschenberger, V. M. O’Connor, T. Nishiki, M. Takahashi, N. Brose, J.-S. Rhee, SNARE Protein Recycling by αSNAP and βSNAP Supports Synaptic Vesicle Priming. Neuron 68, 473–487 (2010).
PNAS
Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals
J. Kim, S.-Y. Jung, Y. K. Lee, S. Park, J.-S. Choi, C. J. Lee, H.-S. Kim, Y.-B. Choi, P. Scheiffele, C. H. Bailey, E. R. Kandel, J.-H. Kim, Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals. Proc. Natl. Acad. Sci. U.S.A. 105, 9087–9092 (2008).
Advanced Materials
Plant‐Based Shape Memory Cryogel for Hemorrhage Control
Deng, Jingyu, Ze Zhao, Xin Yi Yeo, Chunmo Yang, Jueying Yang, Abdul Rahim Ferhan, B. Jin, Chansik Oh, Sangyong Jung*, Subra Suresh*, Namjoon Cho*. ‘Plant‐Based Shape Memory Cryogel for Hemorrhage Control’. Advanced Materials, July, 2024. https://doi.org/10.1002/adma.202311684.
*Corresponding authors
Molecular Nutrition & Food Research
Polar lipids supplementation enhances basal excitatory synaptic transmission in primary cortical neuron
Yeo, Xin Yi, Tam Dao, Yunju Jo, Jung Kim, Dongryeol Ryu, Jia Chan, and Sangyong Jung. ‘Polar Lipids Supplementation Enhances Basal Excitatory Synaptic Transmission in Primary Cortical Neuron’. Molecular Nutrition & Food Research, June, 2024. https://doi.org/10.1002/mnfr.202300883.
Frontiers in Immunology
Emergence of the Brain-Border Immune Niches and Their Contribution to the Development of Neurodegenerative Diseases
Tan, Li Yang, Grace Cunliffe, Michael Patrick Hogan, Xin Yi Yeo, Chansik Oh, Bohwan Jin, Junmo Kang, Junho Park, Min-Soo Kwon, MinYoung Kim, and Sangyong Jung. "Emergence of the Brain-Border Immune Niches and Their Contribution to the Development of Neurodegenerative Diseases." Frontiers in Immunology, May 15, 2024, https//doi.org/0.3389/fimmu.2024.1380063.
Antioxidants
A Consolidated Understanding of the Contribution of Redox Dysregulation in the Development of Hearing Impairment
Yeo, Xin Yi, Soohyun Kwon, Kimberley R. Rinai, Sungsu Lee, Sangyong Jung*, and Raekil Park*. "A Consolidated Understanding of the Contribution of Redox Dysregulation in the Development of Hearing Impairment". Antioxidants 13(5):598, 2024, https//doi.org/10.3390/antiox13050598
*Corresponding authors
ACS Nano
Elucidating Structural Configuration of Lipid Assemblies for mRNA Delivery Systems
Tae, Hyunhyuk, Soohyun Park, Li Yang Tan, Chungmo Yang, Yong-An Lee, Younghwan Choe, Torsten Wüstefeld, Sangyong Jung*, and Nam-Joon Cho*. “Elucidating Structural Configuration of Lipid Assemblies for mRNA Delivery Systems.” ACS Nano, April 19, 2024, acsnano.4c00587. https://doi.org/10.1021/acsnano.4c00587.
*Corresponding authors
eLife
CaBP1 and 2 Enable Sustained CaV1.3 Calcium Currents and Synaptic Transmission in Inner Hair Cells
Oestreicher, David, Shashank Chepurwar, Kathrin Kusch, Vladan Rankovic, Sangyong Jung, Nicola Strenzke, and Tina Pangrsic. “CaBP1 and 2 Enable Sustained CaV1.3 Calcium Currents and Synaptic Transmission in Inner Hair Cells.” Preprint, January 17, 2024. https://doi.org/10.7554/eLife.93646.1.